Co-administration of pramlintide with either the sympathomimetic sibutramine or phentermine was observed to result in 9.2 kg weight loss compared with placebo over 24 weeks, whereas pramlintide monotherapy resulted in just 1.5 kg additional weight loss [79]
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It works by regulating blood sugar and appetite and is, therefore, used in diabetic patients for the management of the condition
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Later, due to its significant and sustained body body mass reduction effect in clinical observations, it was officially approved for the treatment of obesity, bringing a new option for patients with body mass management needs